RT Journal Article
SR Electronic
T1 Nuclear Phospholipase C Signaling Through Type 1 IGF Receptor and its Involvement in Cell Growth and Differentiation
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2039
OP 2041
VO 25
IS 3B
A1 IRENE FAENZA
A1 ANNA MARIA BILLI
A1 MATILDE YUNG FOLLO
A1 ROBERTA FIUME
A1 ALBERTO MARIA MARTELLI
A1 LUCIO COCCO
A1 LUCIA MANZOLI
YR 2005
UL http://ar.iiarjournals.org/content/25/3B/2039.abstract
AB The existence of a nuclear polyphosphoinositol metabolism, independent from that at the plasma cell membrane, is now widely recognized. Specific changes in the nuclear phosphatidylinositol (PtdIns) metabolism have been implicated in cell growth, differentiation and neoplastic transformation. Here, the main features of nuclear inositol lipid signaling through type I IGF receptor, is reviewed with particular attention to the role of inositide-specific phospholipase C (PI-PLC),1 in cell proliferation and differentiation, due to the peculiar localization of this molecule in the nuclear compartment. Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved