RT Journal Article SR Electronic T1 Leptomeningeal Gliomatosis: A Single Institution Study of 31 Patients JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 1035 OP 1041 DO 10.21873/anticanres.13210 VO 39 IS 2 A1 DIDIER AUTRAN A1 MARYLINE BARRIE A1 MONA MATTA A1 COLETTE MONSERRAT A1 CHANTAL CAMPELLO A1 GREGORIO PETRIRENA A1 CELINE BOUCARD A1 LAETITIA PADOVANI A1 ANDERSON LOUNDOU A1 ROMAIN APPAY A1 THOMAS GRAILLON A1 HENRY DUFOUR A1 DOMINIQUE FIGARELLA-BRANGER A1 OLIVIER CHINOT A1 EMELINE TABOURET YR 2019 UL http://ar.iiarjournals.org/content/39/2/1035.abstract AB Background/Aim: Secondary leptomeningeal gliomatosis (LG) is a rare and severe progression pattern of glioma. Our objective was to evaluate the characteristics and outcome of patients with LG. Patients and Methods: We retrospectively reviewed 31 patients diagnosed with secondary LG. At the time of LG diagnosis, the median age of patients was 45 years. The histological grade was IV in 20 patients and II to III in 11 patients. As a first-line of therapy for LG, 22 patients received an oncological treatment: i) BCNU-temozolomide (TMZ) (n=15), ii) other type of chemotherapy (n=7), and iii) no treatment (supportive care) (n=9). Results: Following LG diagnosis, the median progression-free survival (PFS) and overall survival (OS) were 1.8 months [95% confidence interval (CI)=0.9-2.7] and 2.1 months (95%CI=1.3-3), respectively. The univariate analyses showed an improved OS with age of less than 45 years (p<0.001), a prolonged interval from the initial glioma diagnosis (IGD) to LG diagnosis (p=0.003), BCNU–TMZ as the preferred first-line treatment for LG out of the three options (p=0.008), and Karnofsky performance status (KPS) ≥70 (p=0.012). Prolonged interval from IGD to LG diagnosis (HR=5.839) and BCNU–TMZ as the chosen first-line treatment for LG (HR=6.635) remained significant in the multivariate analyses as well. Among the 22 treated patients, the median OS was significantly higher (p=0.008) with the BCNU–TMZ treatment (5.7 months; 95%CI=4.2-7.1), compared to other types of treatment offered (2 months; 95%CI=1.1-2.9). Conclusion: The time interval from the IGD to the LG diagnosis is a potential prognostic factor for LG. BCNU–TMZ may be a therapeutic option in the present setting.