PT  - JOURNAL ARTICLE
AU  - JANNICA MEKLIN
AU  - MAARET ESKELINEN
AU  - DENISE PEIXOTO GUIMARAES
AU  - TUOMAS SELANDER
AU  - TAPANI TIUSANEN
AU  - KARI SYRJÄNEN
AU  - MATTI ESKELINEN
TI  - The Automatically Analyzed (AA) ColonView (CV) Quick Test for Fecal Occult Blood Shows Higher Diagnostic Accuracy in Detection of Colorectal Adenoma than Visually Analyzed Tests
AID  - 10.21873/anticanres.15365
DP  - 2021 Nov 01
TA  - Anticancer Research
PG  - 5517--5525
VI  - 41
IP  - 11
4099  - http://ar.iiarjournals.org/content/41/11/5517.short
4100  - http://ar.iiarjournals.org/content/41/11/5517.full
SO  - Anticancer Res2021 Nov 01; 41
AB  - Background/Aim: The present study compared the accuracy of visually analyzed (VA) and automatically analyzed (AA) ColonView (CV) quick test; a new-generation fecal immunochemical test (FIT) for hemoglobin (Hb) and hemoglobin/haptoglobin (Hb/Hp) (Biohit Oyj, Helsinki, Finland) in subjects participating in colorectal neoplasia (CRN) detection in Brazil. A traditional guaiac-based fecal occult blood test (gFOBT) test (HemoccultSENSA) was used as a reference. Patients and Methods: A cohort of 509 colonoscopy-referral patients were asked to collect three consecutive fecal samples, to be analyzed by both CV and SENSA. Results: In ROC analysis for the AA reading, the optimal cut-off value for CV Hb was ≥8.0912 and that for CV Hb/Hp was ≥1.8983. With these cut-offs, the sensitivity (Se), specificity (Sp), and efficiency of CV AA in detecting colorectal adenoma (CRA) were: 64.2%/78.6%, 53.4%/35.3%, and 58.6%/56.5%, for Hb and Hb/Hp, respectively. In the HSROC analysis, the AUC values for i) VA and ii) AA modes were as follows: i) AUC=0.551 (95%CI=0.500-0.602), ii) AUC=0.606 (95%CI=0.550-0.662). The difference between these AUC values was statistically significant (p=0.0160). Conclusion: The present study confirms the previous results on the applicability of the ColonView quick test in CRN screening. Of the two optional reading modes, the AA reading showed significantly better diagnostic accuracy as compared to the VA reading (or SENSA), in detecting the CRA endpoint in colonoscopy-referral patients.