TY - JOUR T1 - A Novel Predictive Model for Anastomotic Leakage in Colorectal Cancer Using Auto-artificial Intelligence JF - Anticancer Research JO - Anticancer Res SP - 5821 LP - 5825 DO - 10.21873/anticanres.15400 VL - 41 IS - 11 AU - JUNICHI MAZAKI AU - KENJI KATSUMATA AU - YUKI OHNO AU - RYUTARO UDO AU - TOMOYA TAGO AU - KENTA KASAHARA AU - HIROSHI KUWABARA AU - MASANOBU ENOMOTO AU - TETSUO ISHIZAKI AU - YUICHI NAGAKAWA AU - AKIHIKO TSUCHIDA Y1 - 2021/11/01 UR - http://ar.iiarjournals.org/content/41/11/5821.abstract N2 - Aim: Anastomotic leakage (AL) in left-sided colorectal cancer is a serious complication, with an incidence rate of 6-18%. We developed a novel predictive model for AL in colorectal surgery with double-stapling technique (DST) anastomosis using auto-artificial intelligence (AI). Patients and Methods: A total of 256 patients who underwent curative surgery for left-sided colorectal cancer between 2017 and 2021 were included. In addition to conventional clinicopathological factors, we included the type of circular stapler using DST, conventional double-row circular stapler (DCS) or EEA™ circular stapler with Tri-Staple™ technology, 28 mm Medium/Thick (Covidien, New Haven, CT, USA) which had triple-row circular stapler (TCS) as a covariate. Auto-AI software Prediction One (Sony Network Communications Inc.) was used to predict AL with 5-fold cross validation. Predictive accuracy was assessed using the area under the receiver operating characteristic curve. Prediction One also evaluated the ‘importance of variables’ (IOV) using a method based on permutation feature importance. Results: The area under the curve of the AI model was 0.766. The type of circular stapler used was the most influential factor contributing to AL (IOV=0.551). Conclusion: This auto-AI predictive model demonstrated an improvement in accuracy compared to the conventional model. It was suggested that use of a TCS may contribute to a reduction in the AL rate. ER -