PT  - JOURNAL ARTICLE
AU  - BUHMEIDA, ABDELBASET
AU  - RISTAMÄKI, RAIJA
AU  - LAMLUM, HANAN
AU  - BENDARDAF, RIYAD
AU  - HEIKKILÄ, SUVI
AU  - COLLAN, YRJÖ
AU  - SYRJÄNEN, KARI
AU  - PYRHÖNEN, SEPPO
TI  - Nuclear Area is a Prognostic Determinant in Advanced Colorectal Cancer
DP  - 2005 Jul 01
TA  - Anticancer Research
PG  - 3083--3088
VI  - 25
IP  - 4
4099  - http://ar.iiarjournals.org/content/25/4/3083.short
4100  - http://ar.iiarjournals.org/content/25/4/3083.full
SO  - Anticancer Res2005 Jul 01; 25
AB  - Background: The prognostic value of morphometric nuclear features in Dukes' Stages B/C and D colorectal cancer (CRC) was assessed. Patients and Methods: Primary tumours from 86 CRC patients were analysed, using an image overlay drawing system (Prodit Morphometry Program), for the following nuclear features: area, perimeter, diameter, form factor, roundness. Results: The median nuclear area (NA) was 104.6 μm2 (range 57.2 - 237.2 μm2). The NA was larger in patients with lymph node metastasis (p<0.02). Altogether, 43% of the patients showed clinical response to irinotecan-based chemotherapy. All six patients with complete response (CR) had a NA above the median (p<0.03). The disease-specific survival of the patients with a NA above the median was significantly better than in patients with smaller NA (p<0.02). Conclusion: Using the median NA as the cut-off value seems to effectively discriminate patients who are likely to respond to irinotecan-based chemotherapy (with improved prognosis) from those who are non-responsive and develop progressive disease. Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved