PT  - JOURNAL ARTICLE
AU  - OMIYA, SATOSHI
AU  - KOMATSU, SHOHEI
AU  - KIDO, MASAHIRO
AU  - KURAMITSU, KAORI
AU  - GON, HIDETOSHI
AU  - FUKUSHIMA, KENJI
AU  - URADE, TAKESHI
AU  - SO, SHINICHI
AU  - SOFUE, KEITARO
AU  - YANO, YOSHIHIKO
AU  - SAKAI, YOSHITADA
AU  - YANAGIMOTO, HIROAKI
AU  - TOYAMA, HIROCHIKA
AU  - AJIKI, TETSUO
AU  - FUKUMOTO, TAKUMI
TI  - Impact of Sarcopenia as a Prognostic Factor on Reductive Hepatectomy for Advanced Hepatocellular Carcinoma
AID  - 10.21873/anticanres.15394
DP  - 2021 Nov 01
TA  - Anticancer Research
PG  - 5775--5783
VI  - 41
IP  - 11
4099  - http://ar.iiarjournals.org/content/41/11/5775.short
4100  - http://ar.iiarjournals.org/content/41/11/5775.full
SO  - Anticancer Res2021 Nov 01; 41
AB  - Background/Aim: Sarcopenia has been reported to be a significant prognostic factor in patients with hepatocellular carcinoma in recent years. This study aimed to clarify the prognostic significance of sarcopenia in advanced hepatocellular carcinoma treated with reductive hepatectomy. Patients and Methods: We retrospectively analyzed 93 patients who underwent reductive hepatectomy for advanced hepatocellular carcinoma. Results: Median survival time of the sarcopenia group (16.4 months) was significantly shorter than that of the non-sarcopenia group (20.4 months). The overall survival rates at 1, 3, and 5 years of the sarcopenia group were significantly lower than those of the non-sarcopenia group (57.9%, 8.6%, and 2.9% vs. 67.3%, 29.2%, and 15.7%, respectively; p=0.035). On multivariate analysis, sarcopenia was a significant risk factor of overall survival (hazard ratio=1.60, 95% confidence interval=1.00-2.56, p=0.049). Conclusion: Sarcopenia was a significant prognostic factor of survival after reductive hepatectomy in advanced hepatocellular carcinoma.