PT - JOURNAL ARTICLE AU - YOSHIE TSUJIYA AU - MOTOHIRO YAMAMORI AU - AI HASEGAWA AU - YURIE YAMAMOTO AU - MASAKAZU YASHIRO AU - NOBORU OKAMURA TI - Telmisartan Exerts Cytotoxicity in Scirrhous Gastric Cancer Cells by Inducing G<sub>0</sub>/G<sub>1</sub> Cell Cycle Arrest AID - 10.21873/anticanres.15358 DP - 2021 Nov 01 TA - Anticancer Research PG - 5461--5468 VI - 41 IP - 11 4099 - http://ar.iiarjournals.org/content/41/11/5461.short 4100 - http://ar.iiarjournals.org/content/41/11/5461.full SO - Anticancer Res2021 Nov 01; 41 AB - Background/Aim: This study aimed to assess the effects of telmisartan (TEL), a potential antitumor agent, and its mechanism of action in the regulation of apoptosis, autophagy, and cell cycle in scirrhous gastric cancer (SGC). Materials and Methods: The effect of TEL on the viability and chromatin condensation of OCUM-2M and OCUM-12 cells was assessed. Protein expression and the cell cycle were analysed using western blotting and flow cytometry, respectively. Results: TEL inhibited cell proliferation in a dose-dependent manner and increased chromatin condensation and autophagy marker LC3-II levels in OCUM-12 cells. TEL also increased the proportion of cells in the G0/G1 phase transition. Conclusion: Apoptosis and autophagy are partially involved in the inhibitory effect of TEL on cell proliferation. Additionally, TEL caused G0/G1 cell cycle arrest. Therefore, TEL could be a promising treatment for SGC.