TY - JOUR T1 - Brain Metastasis in Soft Tissue Sarcoma at Initial Presentation JF - Anticancer Research JO - Anticancer Res SP - 5611 LP - 5616 DO - 10.21873/anticanres.15376 VL - 41 IS - 11 AU - RYO ITOGA AU - MASATAKE MATSUOKA AU - TOMOHIRO ONODERA AU - ISAO YOKOTA AU - KOJI IWASAKI AU - SHINJI MATSUBARA AU - RYOSUKE HISHIMURA AU - YUKI SUZUKI AU - AKIRA IWATA AU - EIJI KONDO AU - NORIMASA IWASAKI Y1 - 2021/11/01 UR - http://ar.iiarjournals.org/content/41/11/5611.abstract N2 - Background/Aim: Brain metastasis is a rare condition among patients with soft tissue sarcoma (STS), and its precise incidence remains unclear. The aim of this study was to investigate which patients should be screened for brain metastasis. Patients and Methods: We identified all patients with STS diagnosed between 2010 and 2015 in the SEER database. Incidence of brain metastasis at initial presentation and higher incidence of brain metastasis by histological subtype were investigated. In addition, risk factors for brain metastasis were examined. Results: A total of 26,676 patients were included for analysis, of whom 162 patients (0.6%) had brain metastasis. Alveolar soft part sarcoma (6.3%), malignant hemangioendothelioma (3.1%) and malignant schwannoma (2.6%) showed higher incidence of brain metastasis. Deep-rooted tumor, trunk tumor, and histological high-grade tumor tended to show higher incidence of brain metastasis. Conclusion: Risk factors for brain metastasis were deep location, trunk development and histologically high-grade tumor, or specific histological subtypes. ER -