RT Journal Article SR Electronic T1 Prognostic Value of Lower Tract Urinary Symptoms in Clinically Regional Lymph Node-positive Prostate Cancer JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 5593 OP 5598 DO 10.21873/anticanres.15373 VO 41 IS 11 A1 LEANDRO BLAS A1 KOSUKE IEIRI A1 MASAKI SHIOTA A1 SHOHEI NAGAKAWA A1 SHIGEHIRO TSUKAHARA A1 TAKASHI MATSUMOTO A1 EIJI KASHIWAGI A1 ARIO TAKEUCHI A1 JUNICHI INOKUCHI A1 KEN-ICHIRO SHIGA A1 AKIRA YOKOMIZO A1 MASATOSHI ETO YR 2021 UL http://ar.iiarjournals.org/content/41/11/5593.abstract AB Background/Aim: To explore the prognostic value of lower urinary tract symptoms (LUTS) in patients with newly diagnosed regional lymph node-positive prostate cancer. Patients and Methods: The prognostic value of LUTS for progression-free (PFS) and overall (OS) survival, as well as the differential prognostic impact of radiotherapy by LUTS was investigated. Results: Univariate Cox-model analysis showed a statistically significantly increased hazard risk for PFS and OS for men with International Prostate Symptom Score (IPSS)≥19 and Overactive Bladder Symptom Score (OABSS) ≥8 at diagnosis. Patients with lower IPSS had a better PFS at 5 years (70.0% vs. 51.9%, p=0.027) and OS at 5 year (89.3% vs. 73.6%, p=0.016). Similarly, a lower OABSS was associated with greater PFS at 5 years (67.4% vs. 23.4%, p<0.001) and OS at 5 years (85.3% vs. 57.1%, p=0.012). Conclusion: IPSS and OABSS were prognostic for PFS and OS in patients with regional lymph node-metastatic prostate cancer.