@article {KOLIALEXI2979, author = {A. KOLIALEXI and G.TH. TSANGARIS and S. KITSIOU and E. KANAVAKIS and A. MAVROU}, title = {Impact of Cytogenetic and Molecular Cytogenetic Studies on Hematologic Malignancies}, volume = {25}, number = {4}, pages = {2979--2983}, year = {2005}, publisher = {International Institute of Anticancer Research}, abstract = {Conventional cytogenetic analysis of chromosome abnormalities in hematologic malignancies is hampered by the low mitotic index and poor quality of metaphases. A range of techniques based on fluorescence in situ hybridization (FISH) has greatly enhanced the identification of non-random translocations and deletions, pinpointing regions which contain genes involved in leukemogenesis. One of the main advantages of FISH is its ability to use non-dividing interphase cells as DNA targets, enabling the screening of large numbers of cells and providing access to a variety of cells with different hematopoetic activity. Furthermore, multicolor FISH (SKY, M-FISH and CGH microarrays) combines the screening potential of cytogenetics with the accuracy of molecular genetics, allowing the visualization of the entire human genome in 24 different colors. Copyright{\textcopyright} 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/25/4/2979}, eprint = {https://ar.iiarjournals.org/content/25/4/2979.full.pdf}, journal = {Anticancer Research} }