RT Journal Article
SR Electronic
T1 AFP-producing Hepatoid Adenocarcinoma in Association with Barrett's Esophagus with Multiple Liver Metastasis Responding to Paclitaxel/CDDP: A Case Report
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2965
OP 2968
VO 25
IS 4
A1 NATSUKO CHIBA
A1 TAKASHI YOSHIOKA
A1 MASATO SAKAYORI
A1 YOSHIKI MIKAMI
A1 SHUKICHI MIYAZAKI
A1 SHOKO AKIYAMA
A1 KAZUNORI OTSUKA
A1 GENGO YAMAURA
A1 HIROYUKI SHIBATA
A1 SYUNSUKE KATO
A1 SATOSHI KATO
A1 CHIKASHI ISHIOKA
YR 2005
UL http://ar.iiarjournals.org/content/25/4/2965.abstract
AB A case of alpha-fetoprotein (AFP)-producing hepatoid adenocarcinoma in association with Barrett's esophagus with multiple liver metastases, responding to chemotherapy, is reported. A 47-year-old man was admitted to our hospital with abdominal pain after subtotal esophagectomy for an esophageal adenocarcinoma in association with Barrett's esophagus, and was diagnosed as having multiple liver tumors. Most tumor markers were normal, but the serum AFP level was markedly elevated. Dynamic computed tomography and ferumoxide enhanced magnetic resonance imaging did not provide evidence of any primary hepatocellular carcinoma. Since microscopic examination of the resected tumor showed a poorly-differentiated adenocarcinoma with hepatoid features displaying AFP-immunoreactivity, the liver tumors were thus considered to be metastatic deposits. Surgery was not feasible so chemotherapeutic agents were tried, and the combination of paclitaxel (TXL) and cisplatin (CDDP) gave a partial response and good control for a period. This is the first report, to our knowledge, of effective chemotherapy for liver metastases from an AFP-producing hepatoid adenocarcinoma of the esophagus. Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved