RT Journal Article
SR Electronic
T1 Postradiation Malignant Fibrous Histiocytoma and Osteosarcoma of a Patient with High Telomerase Activities
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2951
OP 2955
VO 25
IS 4
A1 MATSUO, TOSHIHIRO
A1 SUGITA, TAKASHI
A1 SHIMOSE, SHOJI
A1 KUBO, TADAHIKO
A1 YASUNAGA, YUJI
A1 HIYAMA, EISO
A1 OCHI, MITSUO
YR 2005
UL http://ar.iiarjournals.org/content/25/4/2951.abstract
AB Background: An extremely rare case of postradiation malignant fibrous histiocytoma (MFH) and osteosarcoma (OS) secondary to radiation therapy for leukemia-related osteolytic lesions is presented. In addition, the telomere biology of these tumors was investigated. Case Report: A 14-year-old boy was diagnosed with acute lymphocytic leukemia. The right tibia was irradiated at a total dose of 60 Gy, and the left tibia was irradiated at a total dose of 40 Gy. The left tibia developed MFH and the right tibia developed OS. Results: Telomere reduction (MFH 70.2, OS 70.0%) and high telomerase activities (MFH 12.1, OS 17.7 TPG) were observed. These results reflect an aggressive feature of postradiation sarcomas. Conclusion: Prognosis for patients diagnosed with postradiation sarcoma is poor due to its aggressiveness. However, even if sarcoma occurs after irradiation in more than two fields in a single patient, improvements in prognosis are anticipated with appropriate chemotherapies and wide resection. Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved