RT Journal Article
SR Electronic
T1 Molecular Prognostic Markers in Recurrent and in Non-recurrent Epithelial Ovarian Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2885
OP 2889
VO 25
IS 4
A1 ATTILA DEMETER
A1 ISTVAN SZILLER
A1 ZSOLT CSAPO
A1 JULIANNA OLAH
A1 GERGELY KESZLER
A1 ANDRAS JENEY
A1 ZOLTAN PAPP
A1 MARIA STAUB
YR 2005
UL http://ar.iiarjournals.org/content/25/4/2885.abstract
AB Background: The outcome and prognosis of ovarian cancer is highly variable. The objective of this study was to compare survival and clinicopathological prognostic factors with the expression levels of two matrix metalloproteinases (MMP) and fibronectin as tumor invasion and metastasis markers in ovarian cancer patients. Materials and Methods: Histologically-verified epithelial ovarian tumours from 27 patients were studied. The latent and the activated forms of MMP-2 and MMP-9 were measured as gelatinase activity from tumour extracts and from serum and ascites samples by a zymographic technique. The fibronectin content was quantified by immunoblotting and densitometric analysis. Molecular marker levels were correlated to clinicopathological parameters such as survival and disease recurrence during the median postoperative follow-up period of 30 months. Results: The levels of MMP-9 and fibronectin, but not those of MMP-2, were significantly higher in tumour tissues and in the ascites fluid of the recurrent patient group and the patient group who did not survive, as compared to the non-reccurent cases. Conclusion: Our data support that high expression of MMP-9 and fibronectin indicate poor prognosis for ovarian cancer patients who have similar clinicopathological prognostic factors. Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved