TY - JOUR T1 - Detectability of Lung Nodules in Ultra-low Dose CT JF - Anticancer Research JO - Anticancer Res SP - 5053 LP - 5058 DO - 10.21873/anticanres.15320 VL - 41 IS - 10 AU - SONJA JANSSEN AU - DANIEL OVERHOFF AU - MATTHIAS F. FROELICH AU - STEFAN O. SCHOENBERG AU - NILS RATHMANN Y1 - 2021/10/01 UR - http://ar.iiarjournals.org/content/41/10/5053.abstract N2 - Background/Aim: Investigation of the influence of different ultra-low dose computed tomography (ULDCT) protocols on the detection of solid and subsolid nodules in a phantom study. Patients and Methods: A chest phantom with pulmonary nodules was scanned with different CT protocols ranging from ultra-low dose settings with spectral shaping to a standard low dose lung cancer screening protocol. Image analysis was performed with different reconstruction algorithms and dedicated computer aided detection (CAD), which was compared to manual readout. Results: The highest sensitivity rates (83%) were achieved for the 90 mAs and 120 mAs protocols when reconstructed with ADMIRE 3 or 5 and manual readout. The only statistically significant difference was found for subsolid nodules with preference of manual readout compared to CAD (p<0.05). Dose levels for the mAs settings ranged from 0.029 to 0.2 mSv. Conclusion: Reliable detectability rates for solid nodules were achieved; CAD software did not prove reliable for subsolid nodules. ER -