TY - JOUR T1 - Comparison Between Second- and Third-generation Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors as First-line Treatment in Patients With Non-small-cell Lung Cancer: A Retrospective Analysis JF - Anticancer Research JO - Anticancer Res SP - 5137 LP - 5145 DO - 10.21873/anticanres.15331 VL - 41 IS - 10 AU - SHO MITSUYA AU - KENJIRO TSURUOKA AU - KIYOE KANAOKA AU - TOMOYA FUNAMOTO AU - HIROYUKI TSUJI AU - NINSO MATSUNAGA AU - TAKAHIKO NAKAMURA AU - YOSUKE TAMURA AU - MASAFUMI IMANISHI AU - SOICHIRO IKEDA AU - YASUHITO FUJISAKA AU - ISAO GOTO AU - AKIHISA IMAGAWA Y1 - 2021/10/01 UR - http://ar.iiarjournals.org/content/41/10/5137.abstract N2 - Background: For epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC), administration of EGFR tyrosine kinase inhibitors (TKIs) is mandatory to prolong survival. To date, a comparison of second- and third-generation EGFR-TKIs has not been reported as far as we are aware. Patients and Methods: We retrospectively investigated the survival time of patients diagnosed with EGFR-mutated advanced or recurrent NSCLC who had received afatinib, a second-generation EGFR-TKI, or osimertinib, a third-generation EGFR-TKI, as the first-line treatment. Results: Among the 49 patients included in the study, 15 received afatinib and 34 received osimertinib. No significant differences in overall survival were observed between the two groups [afatinib vs. osimertinib=36 vs. 33 months (hazard ratio=2.917, 95% confidence interval=0.780-10.905; p=0.112)]. T790M mutation was detected in three of the patients in the afatinib group, and all three subsequently received osimertinib. The median overall survival of these three patients and of the 12 without the mutation were 63 and 36 months, respectively. Conclusion: There was no apparent difference in the effect on survival between second- and third-generation EGFR-TKIs, whereas the sequential administration of second- followed by third-generation EGFR-TKIs appeared to confer a better long-term prognosis. ER -