TY - JOUR T1 - Intensity-modulated Radiotherapy in Patients With Aggressive Extranodal Non-Hodgkin Lymphoma of the Head and Neck JF - Anticancer Research JO - Anticancer Res SP - 5131 LP - 5135 DO - 10.21873/anticanres.15330 VL - 41 IS - 10 AU - JENS EISMANN AU - KHALED ELSAYAD AU - DANIEL ROLF AU - IQBAL SARIF AU - EVA WARDELMANN AU - HENDRIK BERSSENBRÜGGE AU - GEORG LENZ AU - HANS THEODOR EICH Y1 - 2021/10/01 UR - http://ar.iiarjournals.org/content/41/10/5131.abstract N2 - Background/Aim: Image-guided intensity-modulated radiotherapy (IG-IMRT) is increasingly being used to treat patients with head and neck malignancies. This analysis compared conventional radiotherapy (CRT) and IMRT outcomes for head and neck aggressive extranodal non-Hodgkin lymphomas (EN-NHL). Patients and Methods: Forty-eight patients who underwent irradiation between 2005 and 2019 were identified. Results: The median follow-up was 42 months. Patients treated with IMRT experienced higher overall responde rate than patients who received 3DCRT (85% vs. 73%, p=0.4). There was non-significant longer survival following IMRT compared with 3DCRT in terms of 5-year OS (p=0.16). Complete responders after primary treatments had a significantly higher 5-year progression-free (p<0.001) and overall survival (p=0.003) in comparison with those without a complete response. Regarding toxicities, IMRT was associated with less acute and chronic adverse events. Conclusion: IG-IMRT following systemic therapy seems to be associated with a favorable survival and toxicity profile in patients with EN-NHL. ER -