TY - JOUR T1 - An Experimental Study on the Therapeutic Effect of Consecutive Low-dose Cisplatin with Caffeine in Sarcoma-bearing Mice JF - Anticancer Research JO - Anticancer Res SP - 2777 LP - 2784 VL - 25 IS - 4 AU - AKIRA TAKEDA AU - HIROYUKI TSUCHIYA AU - TAKAHIRO TAJINO AU - SHIN-ICHI KIKUCHI Y1 - 2005/07/01 UR - http://ar.iiarjournals.org/content/25/4/2777.abstract N2 - The aims of this study were to investigate the anti-tumor effects of consecutive low-dose cisplatin (LD-CDDP) in comparison with single high-dose CDDP (HD-CDDP) in combination with caffeine. Materials and Methods: Human fibrosarcoma cells (HT-1080) were transplanted in BALB/C-nu mice. According to the administration of CDDP and caffeine, 5 groups were defined: HD-CDDP, LD-CDDP, HD-CDDP +caffeine, LD-CDDP +caffeine and control group. The total dose of CDDP was 3.5 or 6 mg/kg. CDDP was injected i.p. bolus (HD-CDDP) or divided into 5 days (LD-CDDP). Caffeine was injected i.p. at a dose of 60 mg/kg twice a day for 4 days. Results: Significant inhibition of tumor growth and prolongation of survival time were recognized in the HD- and LD-CDDP groups with and without caffeine compared to the control group. The caffeine-assisted groups had no advantage compared to the CDDP alone groups. Conclusion: The effects of LD-CDDP were similar to the effect of HD-CDDP. Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved ER -