@article {TAKEDA2777, author = {AKIRA TAKEDA and HIROYUKI TSUCHIYA and TAKAHIRO TAJINO and SHIN-ICHI KIKUCHI}, title = {An Experimental Study on the Therapeutic Effect of Consecutive Low-dose Cisplatin with Caffeine in Sarcoma-bearing Mice}, volume = {25}, number = {4}, pages = {2777--2784}, year = {2005}, publisher = {International Institute of Anticancer Research}, abstract = {The aims of this study were to investigate the anti-tumor effects of consecutive low-dose cisplatin (LD-CDDP) in comparison with single high-dose CDDP (HD-CDDP) in combination with caffeine. Materials and Methods: Human fibrosarcoma cells (HT-1080) were transplanted in BALB/C-nu mice. According to the administration of CDDP and caffeine, 5 groups were defined: HD-CDDP, LD-CDDP, HD-CDDP +caffeine, LD-CDDP +caffeine and control group. The total dose of CDDP was 3.5 or 6 mg/kg. CDDP was injected i.p. bolus (HD-CDDP) or divided into 5 days (LD-CDDP). Caffeine was injected i.p. at a dose of 60 mg/kg twice a day for 4 days. Results: Significant inhibition of tumor growth and prolongation of survival time were recognized in the HD- and LD-CDDP groups with and without caffeine compared to the control group. The caffeine-assisted groups had no advantage compared to the CDDP alone groups. Conclusion: The effects of LD-CDDP were similar to the effect of HD-CDDP. Copyright{\textcopyright} 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/25/4/2777}, eprint = {https://ar.iiarjournals.org/content/25/4/2777.full.pdf}, journal = {Anticancer Research} }