RT Journal Article SR Electronic T1 Can D3 Lymph Node Dissection for Patients With Colon Cancer With a Poor C-Reactive Protein/Albumin Ratio Improve Survival Outcomes? JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 5097 OP 5106 DO 10.21873/anticanres.15326 VO 41 IS 10 A1 YOSUKE ATSUMI A1 MASAKATSU NUMATA A1 KEISUKE KAZAMA A1 SHINNOSUKE KAWAHARA A1 MIHWA JU A1 KENTA IGUCHI A1 SHO SAWAZAKI A1 TORU AOYAMA A1 AYAKO TAMAGAWA A1 SUMITO SATO A1 AKIO HIGUCHI A1 NOBUHIRO SUGANO A1 TENI GODAI A1 HIROSHI TAMAGAWA A1 HIROYUKI SAEKI A1 TAKASHI OSHIMA A1 MANABU SHIOZAWA A1 NORIO YUKAWA A1 YASUSHI RINO YR 2021 UL http://ar.iiarjournals.org/content/41/10/5097.abstract AB Aim: D3 lymph node dissection (LND) for stage II and III colon cancer has been shown to improve prognosis, however, it generally increases surgical stress. Studies have reported that the C-reactive protein/albumin ratio (CAR) may be a useful inflammatory-nutritional biomarker to predict postoperative complications and poor prognosis for with various types of cancer. Our purposes were to assess the short- and long-term outcomes of D3 LND in patients with a high preoperative CAR (≥ 0.04). Patients and Methods: This was a retrospective cohort analysis reviewing a prospectively collected database of Yokohama City University and three affiliated hospitals. A total of 449 patients with stage II or III colon cancer with high CAR who underwent primary resection with D2 or D3 LND were identified between 2008 and 2020. The primary and secondary outcomes of interests were the 3-year recurrence-free survival and postoperative complication rates. Results: After propensity matching, 230 patients were evaluated. There was no significant difference between the D3 and D2 groups in the rate of postoperative complications overall (14.8% versus 11.3%, p=0.558), however, the incidence of anastomotic leakage tended to be greater in the D3 group (9.6% versus 2.6%, p=0.050). The long-term findings showed that there was no significant difference between the two groups (3-year recurrence-free survival rate: 77.2% versus 77.2%, p=0.880). Conclusion: D3 LND did not improve survival outcomes for patients with colon cancer with a poor CAR in this study. D2 LND may be a treatment option for patients with stage II-III colon cancer with a high preoperative CAR.