TY - JOUR T1 - Updated Outcomes of Split Course Radiotherapy in Elderly or Infirm Patients With Advanced Cancers of the Head and Neck JF - Anticancer Research JO - Anticancer Res SP - 4995 LP - 5000 DO - 10.21873/anticanres.15313 VL - 41 IS - 10 AU - CHAIM DOMB AU - TIMOTHY D. SMILE AU - CHANDANA REDDY AU - NEIL M. WOODY AU - SHAUNA R. CAMPBELL AU - JOYCELIN F. CANAVAN AU - NIKHIL P. JOSHI AU - JOHN F GRESKOVICH AU - DEBORAH J. CHUTE AU - BRIAN B. BURKEY AU - LAMIE A. KU AU - ERIC LAMARRE AU - ROBERT R. LORENZ AU - BRANDON PRENDES AU - JOSEPH SCHARPF AU - LARISA SCHWARTZMAN AU - JESSICA L. GEIGER AU - SHLOMO A. KOYFMAN AU - CHRISTOPHER W. FLEMING Y1 - 2021/10/01 UR - http://ar.iiarjournals.org/content/41/10/4995.abstract N2 - Background/Aim: Head and neck cancers are often treated with extended courses of radiotherapy (RT), which may prove excessively toxic for frail patients. Split course RT (SCRT) delivers two courses of RT separated by 4-6 weeks, personalizing treatment intensity based on response. In this study, we present our updated experience using this technique. Patients and Methods: From a single institution database, we identified patients considered for SCRT. For patients undergoing a second course of RT, cumulative incidence of locoregional recurrence (LRR) and overall survival (OS) are reported. Results: A total of 98 patients were included, of whom seventy-five percent underwent a second course of RT. The most common fractionation was 30 Gy in 10 fractions for each course, with a median cumulative dose of 60 Gy. In those undergoing a second course of RT, median OS was 9.7 months and cumulative incidence of LRR at 6, 12, and 24 months was 17.0%, 23.1%, and 29.4%, respectively. Conclusion: SCRT offers an attractive treatment paradigm to personalize radiation intensity based on patient tolerance, while maintaining reasonable safety and efficacy in those unfit for standard full course RT. ER -