@article {BUYRU2767, author = {NUR BUYRU and AYDA TEZOL and NEJAT DALAY}, title = {p53 Intronic G13964C Variant in Colon Cancer and its Association with HPV}, volume = {25}, number = {4}, pages = {2767--2769}, year = {2005}, publisher = {International Institute of Anticancer Research}, abstract = {Background: Inactivation of p53 is the most common change identified in human cancer. Nucleotide alterations in p53 intron 6 have been reported to be associated with the dysregulation of p53 function and tumor development. The aim of our study was to assess whether the intron 6 G13964C variant of the p53 gene is associated with the presence of human papillomavirus (HPV) as a risk factor in colon cancer. Materials and Methods: To determine whether the intronic G13964C alteration is involved in colon carcinogenesis, surgical specimens from 55 patients with colon cancer and HPV-positive tumors were examined by PCR-RFLP. Blood samples from 77 healthy subjects were used as the control group. Results: The 13964C variant was found in 14.5\% of colon cancer patients and 12.9\% of the control subjects. One patient and two controls were homozygous for this base change. Conclusion: No evidence of a significant association between the p53 G13964C allele and colon carcinoma was found. Copyright{\textcopyright} 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/25/4/2767}, eprint = {https://ar.iiarjournals.org/content/25/4/2767.full.pdf}, journal = {Anticancer Research} }