TY - JOUR T1 - Clinical Predictors of Unresectable Disease at Laparotomy in Patients With Pancreatic Ductal Adenocarcinoma Planning to Undergo Surgical Resection JF - Anticancer Research JO - Anticancer Res SP - 5171 LP - 5177 DO - 10.21873/anticanres.15335 VL - 41 IS - 10 AU - TAKAYUKI SHIMIZU AU - TAKU AOKI AU - SHUN SATO AU - TAKATSUGU MATSUMOTO AU - TAKAYUKI SHIRAKI AU - YUHKI SAKURAOKA AU - SHOZO MORI AU - YUKIHIRO ISO AU - MITSURU ISHIZUKA AU - KEIICHI KUBOTA Y1 - 2021/10/01 UR - http://ar.iiarjournals.org/content/41/10/5171.abstract N2 - Background/Aim: Computed tomography and positron emission tomography cannot detect all minute distant metastases and fully evaluate extensive vascular invasion in patients with pancreatic ductal adenocarcinoma (PDAC). The aim of this study was to investigate predictors of laparotomy only and palliative surgery in PDAC patients planning surgical resection. Patients and Methods: We reviewed 239 PDAC patients planning surgical resection. Patients were divided into two groups based on resection status. Multivariate analyses were performed to identify predictors of unresectable disease at laparotomy. Results: Twenty-five patients had unresectable disease at laparotomy. Multivariate analysis revealed that anatomical borderline resectable status (yes/no) (HR=5.458, p=0.012), pretreatment CA19-9 (>260/≤260 ng/ml) (HR=4.907, p=0.041), and tumor size (>25/≤25 mm) (HR=21.42, p=0.004) were associated with unresectable disease at laparotomy. Conclusion: Borderline resectable status, pretreatment CA19-9, and tumor size were closely associated with unresectable disease at laparotomy in PDAC patients planning surgical resection. ER -