TY - JOUR T1 - Immunonutritional Indices in Non-small-cell Lung Cancer Patients Receiving Adjuvant Platinum-based Chemotherapy JF - Anticancer Research JO - Anticancer Res SP - 5157 LP - 5163 DO - 10.21873/anticanres.15333 VL - 41 IS - 10 AU - TAICHI MATSUBARA AU - FUMIHIKO HIRAI AU - MASAFUMI YAMAGUCHI AU - MOTOHARU HAMATAKE Y1 - 2021/10/01 UR - http://ar.iiarjournals.org/content/41/10/5157.abstract N2 - Background/Aim: Adjuvant platinum-based chemotherapy (APC) has been the standard of care for patients with non-small-cell lung cancer (NSCLC) who have undergone complete pulmonary resection. This study analyzed the clinical and prognostic significance of immunonutritional indices in NSCLC patients receiving APC. Patients and Methods: We retrospectively reviewed 110 patients from 2008 to 2016. Three immunonutritional indices were calculated: neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and prognostic nutritional index (PNI). Results: The median age was 64 years, and 66 patients were males. Each index showed a significant correlation with primary tumor length. NLR and PLR were significantly correlated with vascular invasion. Prognostic analyses revealed that each index was significantly correlated with postoperative recurrence-free survival (RFS) and overall survival (OS). On multivariate analyses, PNI was an independent predictor of RFS and OS. Conclusion: Host immunonutritional status may have a significant effect on the postoperative prognosis of NSCLC in patients receiving APC. ER -