PT  - JOURNAL ARTICLE
AU  - ERI ODA
AU  - KENSUKE YAMAMURA
AU  - YOSHIHIRO HARA
AU  - KAZUKI MATSUMURA
AU  - SHINICHI AKAHOSHI
AU  - HIDEAKI YUKI
AU  - TOSHIHIKO MOTOHARA
AU  - HIDEAKI MIYAMOTO
AU  - KOICHI KINOSHITA
AU  - FUJIO MATSUMURA
AU  - KOJI OHNISHI
AU  - YOSHIHIRO KOMOHARA
AU  - TORU BEPPU
TI  - Intrahepatic Cholangiocarcinoma Coexisting With Multiple Bile Duct Adenoma Treated as Liver Metastasis from a Pancreatic Neuroendocrine Tumor
AID  - 10.21873/anticanres.15344
DP  - 2021 Oct 01
TA  - Anticancer Research
PG  - 5249--5254
VI  - 41
IP  - 10
4099  - http://ar.iiarjournals.org/content/41/10/5249.short
4100  - http://ar.iiarjournals.org/content/41/10/5249.full
SO  - Anticancer Res2021 Oct 01; 41
AB  - Background: Bile duct adenomas (BDA) may be precursor lesions of small duct-type, including mass-forming type intrahepatic cholangiocarcinoma (ICC). Case Report: A 68-year-old woman was transferred to our facility for the treatment of a liver tumor, possibly metastasized from a pancreatic neuroendocrine tumor. Finally, two liver tumors were resected and histopathologically diagnosed as “BDA” and “ICC with a BDA-like component”. In the BDA-like component, the MUC6 positive rate was notably lower and the Ki-67 positive rate was higher than the other BDAs and ICC component, respectively. The doubling time of the tumor volume in BDA was very long but was shortened (1,510 and 719 days). Distinct enlargement of the tumor and appearance of enhancement through diagnostic imaging was useful in diagnosing the transformation from a BDA to an ICC. Conclusion: An “adenoma-carcinoma sequence” may exist in the transformation process from a BDA to an ICC.