RT Journal Article SR Electronic T1 Acetyl-L-Carnitine Prevents and Reverts Experimental Chronic Neurotoxicity Induced by Oxaliplatin, Without Altering its Antitumor Properties JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 2681 OP 2687 VO 25 IS 4 A1 ORLANDO GHIRARDI A1 PIETRO LO GIUDICE A1 CLAUDIO PISANO A1 MARIO VERTECHY A1 AUGUSTA BELLUCCI A1 LOREDANA VESCI A1 SANTE CUNDARI A1 MARIAROSARIA MILOSO A1 LAURA MARIA RIGAMONTI A1 GABRIELLA NICOLINI A1 CLAUDIO ZANNA A1 PAOLO CARMINATI YR 2005 UL http://ar.iiarjournals.org/content/25/4/2681.abstract AB Background: Oxaliplatin (OHP) is severely neurotoxic and induces the onset of a disabling sensory peripheral neuropathy. Acetyl-L-carnitine (ALC), a natural compound with neuroprotective action, was tested to determine whether it plays a protective role in OHP-induced neuropathy. Materials and Methods: Peripheral neuropathy was induced in Wistar rats, and the effect of OHP alone or in combination with ALC was assessed, using behavioral and neurophysiological methods. Moreover, ALC interference on OHP antitumor activity was investigated using several in vitro and in vivo models. Results: ALC-co-treatment reduced the neurotoxicity of OHP when it was coadministered. Furthermore, the administration of OHP, once OHP-induced neuropathy was established, significantly mitigated its severity. Finally, experiments in different tumor systems indicated that ALC does not interfere with the antitumor effects of OHP. Conclusion: ALC is effective in the prevention and treatment of chronic OHP-induced peripheral neurotoxicity in an experimental rat model. Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved