PT  - JOURNAL ARTICLE
AU  - ORLANDO GHIRARDI
AU  - PIETRO LO GIUDICE
AU  - CLAUDIO PISANO
AU  - MARIO VERTECHY
AU  - AUGUSTA BELLUCCI
AU  - LOREDANA VESCI
AU  - SANTE CUNDARI
AU  - MARIAROSARIA MILOSO
AU  - LAURA MARIA RIGAMONTI
AU  - GABRIELLA NICOLINI
AU  - CLAUDIO ZANNA
AU  - PAOLO CARMINATI
TI  - Acetyl-L-Carnitine Prevents and Reverts Experimental Chronic Neurotoxicity Induced by Oxaliplatin, Without Altering its Antitumor Properties
DP  - 2005 Jul 01
TA  - Anticancer Research
PG  - 2681--2687
VI  - 25
IP  - 4
4099  - http://ar.iiarjournals.org/content/25/4/2681.short
4100  - http://ar.iiarjournals.org/content/25/4/2681.full
SO  - Anticancer Res2005 Jul 01; 25
AB  - Background: Oxaliplatin (OHP) is severely neurotoxic and induces the onset of a disabling sensory peripheral neuropathy. Acetyl-L-carnitine (ALC), a natural compound with neuroprotective action, was tested to determine whether it plays a protective role in OHP-induced neuropathy. Materials and Methods: Peripheral neuropathy was induced in Wistar rats, and the effect of OHP alone or in combination with ALC was assessed, using behavioral and neurophysiological methods. Moreover, ALC interference on OHP antitumor activity was investigated using several in vitro and in vivo models. Results: ALC-co-treatment reduced the neurotoxicity of OHP when it was coadministered. Furthermore, the administration of OHP, once OHP-induced neuropathy was established, significantly mitigated its severity. Finally, experiments in different tumor systems indicated that ALC does not interfere with the antitumor effects of OHP. Conclusion: ALC is effective in the prevention and treatment of chronic OHP-induced peripheral neurotoxicity in an experimental rat model. Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved