@article {GHIRARDI2681, author = {ORLANDO GHIRARDI and PIETRO LO GIUDICE and CLAUDIO PISANO and MARIO VERTECHY and AUGUSTA BELLUCCI and LOREDANA VESCI and SANTE CUNDARI and MARIAROSARIA MILOSO and LAURA MARIA RIGAMONTI and GABRIELLA NICOLINI and CLAUDIO ZANNA and PAOLO CARMINATI}, title = {Acetyl-L-Carnitine Prevents and Reverts Experimental Chronic Neurotoxicity Induced by Oxaliplatin, Without Altering its Antitumor Properties}, volume = {25}, number = {4}, pages = {2681--2687}, year = {2005}, publisher = {International Institute of Anticancer Research}, abstract = {Background: Oxaliplatin (OHP) is severely neurotoxic and induces the onset of a disabling sensory peripheral neuropathy. Acetyl-L-carnitine (ALC), a natural compound with neuroprotective action, was tested to determine whether it plays a protective role in OHP-induced neuropathy. Materials and Methods: Peripheral neuropathy was induced in Wistar rats, and the effect of OHP alone or in combination with ALC was assessed, using behavioral and neurophysiological methods. Moreover, ALC interference on OHP antitumor activity was investigated using several in vitro and in vivo models. Results: ALC-co-treatment reduced the neurotoxicity of OHP when it was coadministered. Furthermore, the administration of OHP, once OHP-induced neuropathy was established, significantly mitigated its severity. Finally, experiments in different tumor systems indicated that ALC does not interfere with the antitumor effects of OHP. Conclusion: ALC is effective in the prevention and treatment of chronic OHP-induced peripheral neurotoxicity in an experimental rat model. Copyright{\textcopyright} 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/25/4/2681}, eprint = {https://ar.iiarjournals.org/content/25/4/2681.full.pdf}, journal = {Anticancer Research} }