RT Journal Article
SR Electronic
T1 <em>S100A2</em> Overexpression is Frequently Observed in Esophageal Squamous Cell Carcinoma
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1247
OP 1250
VO 25
IS 2B
A1 MASAHIKO IMAZAWA
A1 KENJI HIBI
A1 SHIN-ICHI FUJITAKE
A1 YASUHIRO KODERA
A1 KATSUKI ITO
A1 SEIJI AKIYAMA
A1 AKIMASA NAKAO
YR 2005
UL http://ar.iiarjournals.org/content/25/2B/1247.abstract
AB Background: We previously detected that ΔNp63, a human p53 homologue, is an oncogene amplified in squamous cell carcinomas (SCC) including esophageal SCC. Subsequently, we examined global patterns of gene expression in cancer cells following ΔNp63 gene introduction using an oligonucleotide microarray approach. We identified S100A2, a Ca2+-binding protein, as a novel downstream mediator of ΔNp63. Materials and Methods: In this study, we examined S100A2 expression in esophageal SCC cell lines and primary SCCs using Northern analysis. Results: We found that 2 out of 8 (25%) cell lines and 14 out of 30 primary esophageal cancers (47%) showed S100A2 gene overexpression compared to paired normal tissues. To examine a possible relationship between S100A2 overexpression and clinicopathological features, we proceeded with statistical analysis. S100A2 overexpression was significantly associated with higher age in esophageal SCC (p=0.0434). Interestingly, S100A2-overexpressing cancers showed a trend toward preferentially developing lymph node metastases and distant metastases (p=0.111 and 0.178, respectively). Conclusion: These results suggested that S100A2 might be related to the progression of esophageal SCC. Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved