RT Journal Article
SR Electronic
T1 Expression of Dihydropyrimidine Dehydrogenase, Thymidylate Synthase, p53 and p21 in Metastatic Liver Tumor from Colorectal Cancer after 5-Fluorouracil-based Chemotherapy
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1237
OP 1242
VO 25
IS 2B
A1 SHIGERU YAMAGISHI
A1 HIROSHI SHIMADA
A1 TAKASHI ISHIKAWA
A1 SHOUICHI FUJII
A1 KUNIYA TANAKA
A1 HIDENOBU MASUI
A1 SHIGEKI YAMAGUCHI
A1 YASUSHI ICHIKAWA
A1 SHINJI TOGO
A1 HIDEYUKI IKE
YR 2005
UL http://ar.iiarjournals.org/content/25/2B/1237.abstract
AB Background: The expression of genes thought to be related to 5-FU chemosensitivity has been extensively investigated. However, little data is available on the expression patterns of these genes after chemotherapy. Patients and Methods: We investigated the expression of four genes, DPD, TS, p53 and p21, in the metastatic liver lesions obtained from colorectal cancer patients who had been treated with hepatic arterial infusions of 5-fluorouracil(5-FU)-based chemotherapy. Results: Expression of DPD, TS and p53 in the metastatic liver lesions was significantly higher in the chemotherapy-response group than in the no response group. In the response group, viable cancer cell nests were seen in confined spaces surrounded by fibrous tissue. It was of interest that these cancer cells in the response group showed conspicuous immunoreactivity of DPD, TS and p53. Conclusion: An analysis of genes involved in 5-FU sensitivity revealed that surviving tumor cells exhibited resistance characteristics, indicating that the chemotherapy regimen should be altered, even in partially responding cases, unless the response is pathologically complete. Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved