RT Journal Article
SR Electronic
T1 Frailty Can Predict Prognosis After Hepatectomy in Patients With Colorectal Liver Metastasis
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 4637
OP 4644
DO 10.21873/anticanres.15277
VO 41
IS 9
A1 KAZUNORI TOKUDA
A1 YUJI MORINE
A1 KATSUKI MIYAZAKI
A1 SHINICHIRO YAMADA
A1 YU SAITO
A1 MASAAKI NISHI
A1 TETSUYA IKEMOTO
A1 MITSUO SHIMADA
YR 2021
UL http://ar.iiarjournals.org/content/41/9/4637.abstract
AB Background/Aim: The aim of this study was to investigate frailty as a prognostic factor in patients with colorectal liver metastasis undergoing hepatectomy. Patients and Methods: Eighty-seven patients who underwent hepatectomy at our institution were enrolled. Frailty was defined as a score of ≥4 on a clinical frailty scale. Patients were divided into frailty (n=29) and non-frailty (n=58) groups. Results: Overall and cancer-specific survival rates were significantly worse in the frailty group compared with the non-frailty group, and multivariate analysis revealed frailty as an independent prognostic factor. Disease-free survival tended to be worse in the frailty group. Fifty-eight patients relapsed after the first hepatectomy. Twenty-one of 58 recurrent patients were allocated to the frailty group. After recurrence, chemotherapy was significantly more frequently performed in the non-frailty group compared with the frailty group. Conclusion: Frailty can predict the prognosis of patients with colorectal liver metastasis undergoing hepatectomy.