PT  - JOURNAL ARTICLE
AU  - TOKUDA, KAZUNORI
AU  - MORINE, YUJI
AU  - MIYAZAKI, KATSUKI
AU  - YAMADA, SHINICHIRO
AU  - SAITO, YU
AU  - NISHI, MASAAKI
AU  - IKEMOTO, TETSUYA
AU  - SHIMADA, MITSUO
TI  - Frailty Can Predict Prognosis After Hepatectomy in Patients With Colorectal Liver Metastasis
AID  - 10.21873/anticanres.15277
DP  - 2021 Sep 01
TA  - Anticancer Research
PG  - 4637--4644
VI  - 41
IP  - 9
4099  - http://ar.iiarjournals.org/content/41/9/4637.short
4100  - http://ar.iiarjournals.org/content/41/9/4637.full
SO  - Anticancer Res2021 Sep 01; 41
AB  - Background/Aim: The aim of this study was to investigate frailty as a prognostic factor in patients with colorectal liver metastasis undergoing hepatectomy. Patients and Methods: Eighty-seven patients who underwent hepatectomy at our institution were enrolled. Frailty was defined as a score of ≥4 on a clinical frailty scale. Patients were divided into frailty (n=29) and non-frailty (n=58) groups. Results: Overall and cancer-specific survival rates were significantly worse in the frailty group compared with the non-frailty group, and multivariate analysis revealed frailty as an independent prognostic factor. Disease-free survival tended to be worse in the frailty group. Fifty-eight patients relapsed after the first hepatectomy. Twenty-one of 58 recurrent patients were allocated to the frailty group. After recurrence, chemotherapy was significantly more frequently performed in the non-frailty group compared with the frailty group. Conclusion: Frailty can predict the prognosis of patients with colorectal liver metastasis undergoing hepatectomy.