RT Journal Article
SR Electronic
T1 Pathological Roles of Prostaglandin E2-specific E-type Prostanoid Receptors in Hormone-sensitive and Castration-resistant Prostate Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 4333
OP 4341
DO 10.21873/anticanres.15238
VO 41
IS 9
A1 YASUYOSHI MIYATA
A1 MASAHITO MASATO
A1 YUTA MUKAE
A1 YUICHIRO NAKAMURA
A1 TSUYOSHI MATSUDA
A1 JUNKI HARADA
A1 KENSUKE MITSUNARI
A1 TOMOHIRO MATSUO
A1 KOJIRO OHBA
A1 HIDEKI SAKAI
YR 2021
UL http://ar.iiarjournals.org/content/41/9/4333.abstract
AB Background/Aim: Prostaglandin (PG) E2 mediates malignant aggressiveness by binding to four specific E-type prostanoid receptors (EP1R – 4R). This study aimed to clarify the pathological significance of EPRs in hormone-sensitive prostate cancer (HSPC) and castration-resistant prostate cancer (CRPC). Materials and Methods: EP1R – 4R expression was examined in 102 HSPC and 27 CRPC specimens. The relationships between their expression and proliferation index (PI), apoptotic index (AI), and vascular endothelial growth factor (VEGF)-A expression were analyzed. Results: EP4R expression in CRPC was significantly higher compared to that in HSPC, even in advanced disease (T3/4, N1, and/or M1). EP4R expression was significantly correlated with PI, AI, and VEGF-A expression in CRPC. Such significant relationships were not detected between EP1R – 3R and CRPC. Conclusion: EP4R expression in CRPC was significantly higher than that in HSPC and was associated with cancer cell proliferation, apoptosis, and pro-angiogenetic potential.