RT Journal Article
SR Electronic
T1 Telmisartan Facilitates the Anticancer Effects of CARP-1 Functional Mimetic and Sorafenib in Rociletinib Resistant Non-small Cell Lung Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 4215
OP 4228
DO 10.21873/anticanres.15226
VO 41
IS 9
A1 SUNIL KUMAR SURAPANENI
A1 EBONY NOTTINGHAM
A1 ARINDAM MONDAL
A1 NILKUMAR PATEL
A1 PEGGY ARTHUR
A1 ARAGAW GEBEYEHU
A1 ANIL KUMAR KALVALA
A1 ARUN K. RISHI
A1 MANDIP SINGH
YR 2021
UL http://ar.iiarjournals.org/content/41/9/4215.abstract
AB Background/Aim: Tyrosine kinase inhibitors (TKIs) are used for the treatment of both wild type and mutant non-small cell lung cancer (NSCLC); however, acquired resistance is a major clinical challenge. Herein, we aimed to investigate the effects of telmisartan (Tel), CFM 4.16 and sorafenib combination in rociletinib resistant NSCLC tumors. Materials and Methods: 3D spheroid cultures and western blotting were used for evaluating cytotoxic effects and protein expression. An in vivo rociletinib resistant H1975 xenograft model of NSCLC was developed by subcutaneous injection of rociletinib resistant H1975 cells into nude mice. Results: Tel, CFM 4.16 and sorafenib combination displayed superior anti-cancer effects in 3D spheroid cultures and a rociletinib resistant H1975 xenograft model of NSCLC by decreasing the protein expression of oncogenic and cancer stem cell markers (Nanog, Sox2 and Oct4). Conclusion: Tel facilitates effective penetration of CFM 4.16 and sorafenib in rociletinib resistant H1975 models of NSCLC.