RT Journal Article
SR Electronic
T1 Tumor Vascular Microenvironment of Colorectal Hepatic Metastasis and Chemotherapy Response
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 4505
OP 4513
DO 10.21873/anticanres.15261
VO 41
IS 9
A1 HIROTAKA OKAMOTO
A1 SHUGO SHIBA
A1 HIROSHI IINO
A1 MAKOTO SUDOH
A1 DAISUKE ICHIKAWA
YR 2021
UL http://ar.iiarjournals.org/content/41/9/4505.abstract
AB Background: The tumor vascular microenvironment has an important role in tumor progression and metastasis. The objective of this study was to assess the significance of metastatic hepatic tumor vascular microenvironment in relation to the response to systemic fluorouracil-based chemotherapy [folinic acid/fluorouracil/oxaliplatin (FOLFOX) or folinic acid/fluorouracil/irinotecan (FOLFIRI)]. Patients and Methods: A total of 48 consecutive patients with colorectal cancer (CRC) with hepatic metastasis were retrospectively reviewed, and factors such as metastatic tumor vascular microenvironment, chemotherapy response and hepatic resection, were analyzed. Tumor angiogenesis was microscopically evaluated by microvessel density (MVD) in sections stained immunochemically with antibody to CD34 in patients with hepatic resection. Angiogenesis in the tumor microenvironment in association with ring enhancement (RE) on computed tomography (CT) was also examined. Results: Microscopic examination revealed that peripheral RE on CT of the metastatic tumor was associated with tumor angiogenesis by MVD. The overall response rate after six courses of first-line chemotherapy for liver metastasis with RE on CT was 64% (23/36), whereas the response rate for those without RE was 25% (3/12), which was significantly lower, although the survival of patients with RE-positive and RE-negative tumors did not differ significantly. Conclusion: Peripheral RE of metastatic hepatic tumor on CT was associated with angiogenesis in the tumor microenvironment and higher chemotherapy response.