PT - JOURNAL ARTICLE AU - EKIN OZLUK AU - STAVEN PATEL AU - DOMENICO COPPOLA AU - GHALI GHALI AU - JAMES D. COTELINGAM AU - CHRISTOPHER G. KEVIL AU - RODNEY E. SHACKELFORD TI - Cystathionine Gamma-Lyase Is Increased in Testicular Seminomas, Embryonal, and Yolk Sac Tumors AID - 10.21873/anticanres.15225 DP - 2021 Sep 01 TA - Anticancer Research PG - 4211--4214 VI - 41 IP - 9 4099 - http://ar.iiarjournals.org/content/41/9/4211.short 4100 - http://ar.iiarjournals.org/content/41/9/4211.full SO - Anticancer Res2021 Sep 01; 41 AB - Background: Testicular cancer constitutes 1.0% of male cancer and typically carries a good prognosis. As far as we are aware, the role for hydrogen sulfide in testicular cancer and the level of hydrogen sulfide-synthesizing enzyme have never been addressed. Here we examined cystathionine gamma-lyase (CSE) expression in several germ-cell testicular tumors. Materials and Methods: Tissue microarrays were employed to examine CSE expression in 32 benign testicular samples, 88 testicular seminomas, 34 embryonal carcinomas, 4 mature teratomas, and 16 yolk sac tumors, and CSE expression was compared to that seen in benign testicular tissue. Results: Compared to benign testicular tissue, CSE expression was increased in all three types of testicular neoplasm but not in mature teratomas. Highest CSE expression was identified in embryonal carcinomas, which often show a relatively aggressive clinical course. Conclusion: For the first time, we show that CSE is increased in several common testicular germ-cell tumor types.