%0 Journal Article %A DANIEL VITOR DE SOUZA %A MARIA ESTHER SUAREZ ALPIRE %A INGRA TAIS MALACARNE %A GLAUCIA MONTEIRO DE CASTRO %A MILENA DE BARROS VIANA %A REGINA CLAUDIA BARBOSA DA SILVA %A GLENDA NICIOLI DA SILVA %A ANA CLAUDIA MUNIZ RENNO %A DANIEL ARAKI RIBEIRO %T Does Panoramic X-ray Induce Cytogenetic Damage to Oral Cells? A Systematic Review With Meta-analysis %D 2021 %R 10.21873/anticanres.15224 %J Anticancer Research %P 4203-4210 %V 41 %N 9 %X Aim: The aim of this review was to evaluate the scientific literature regarding the cytogenetic damage in oral exfoliated cells of adult patients submitted to panoramic X-ray. Materials and Methods: An extensive search of the literature was conducted on PubMed, Scopus and Web of Science databases for all studies published until April 2021 using combinations of the following keywords: “panoramic X-ray,” “DNA damage,” “genetic damage”, “genotoxicity”, “mutagenicity”, cytotoxicity”, “buccal cells”, “oral mucosa”, “tongue”, “gingiva”, “micronucleus assay”, according to the PRISMA guidelines. All clinical studies in English language were included in the study. A total of 10 studies were identified. Results: As expected, the results regarding the cytogenetic damage induced by panoramic X-ray are conflicting. Some authors have demonstrated that panoramic X-ray induces mutagenesis in oral cells, whereas others did not. After reviewing the 10 studies, two were classified as strong, four were considered moderate, and four were considered weak, according to the quality assessment components of the Effective Public Health Practice Project (EPHPP). Meta-analysis data revealed a negative response related to mutagenicity in oral cells by panoramic X-ray. Conclusion: Taken together, this review failed to demonstrate the association between micronucleus frequency and panoramic X-ray. %U https://ar.iiarjournals.org/content/anticanres/41/9/4203.full.pdf