TY - JOUR T1 - Does Panoramic X-ray Induce Cytogenetic Damage to Oral Cells? A Systematic Review With Meta-analysis JF - Anticancer Research JO - Anticancer Res SP - 4203 LP - 4210 DO - 10.21873/anticanres.15224 VL - 41 IS - 9 AU - DANIEL VITOR DE SOUZA AU - MARIA ESTHER SUAREZ ALPIRE AU - INGRA TAIS MALACARNE AU - GLAUCIA MONTEIRO DE CASTRO AU - MILENA DE BARROS VIANA AU - REGINA CLAUDIA BARBOSA DA SILVA AU - GLENDA NICIOLI DA SILVA AU - ANA CLAUDIA MUNIZ RENNO AU - DANIEL ARAKI RIBEIRO Y1 - 2021/09/01 UR - http://ar.iiarjournals.org/content/41/9/4203.abstract N2 - Aim: The aim of this review was to evaluate the scientific literature regarding the cytogenetic damage in oral exfoliated cells of adult patients submitted to panoramic X-ray. Materials and Methods: An extensive search of the literature was conducted on PubMed, Scopus and Web of Science databases for all studies published until April 2021 using combinations of the following keywords: “panoramic X-ray,” “DNA damage,” “genetic damage”, “genotoxicity”, “mutagenicity”, cytotoxicity”, “buccal cells”, “oral mucosa”, “tongue”, “gingiva”, “micronucleus assay”, according to the PRISMA guidelines. All clinical studies in English language were included in the study. A total of 10 studies were identified. Results: As expected, the results regarding the cytogenetic damage induced by panoramic X-ray are conflicting. Some authors have demonstrated that panoramic X-ray induces mutagenesis in oral cells, whereas others did not. After reviewing the 10 studies, two were classified as strong, four were considered moderate, and four were considered weak, according to the quality assessment components of the Effective Public Health Practice Project (EPHPP). Meta-analysis data revealed a negative response related to mutagenicity in oral cells by panoramic X-ray. Conclusion: Taken together, this review failed to demonstrate the association between micronucleus frequency and panoramic X-ray. ER -