RT Journal Article
SR Electronic
T1 Clinical Significance of Chemokine Receptor CXCR4 and CCR7 mRNA Expression in Patients With Colorectal Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 4489
OP 4495
DO 10.21873/anticanres.15259
VO 41
IS 9
A1 SHINSUKE NAGASAWA
A1 KAZUHITO TSUCHIDA
A1 MANABU SHIOZAWA
A1 YUKIHIKO HIROSHIMA
A1 YAYOI KIMURA
A1 ITARU HASHIMOTO
A1 HAYATO WATANABE
A1 KAZUKI KANO
A1 MASAKATSU NUMATA
A1 TORU AOYAMA
A1 SUMITO SATO
A1 TAKANOBU YAMADA
A1 HIROSHI TAMAGAWA
A1 NAOTO YAMAMOTO
A1 TAKASHI OGATA
A1 SOICHIRO MORINAGA
A1 NORIO YUKAWA
A1 YASUSHI RINO
A1 MUNETAKA MASUDA
A1 HIROSHI SAEKI
A1 YOHEI MIYAGI
A1 TAKASHI OSHIMA
YR 2021
UL http://ar.iiarjournals.org/content/41/9/4489.abstract
AB Background/Aim: The chemokine receptors C-X-C chemokine receptor type 4 (CXCR4) and C-C chemokine receptor type 7 (CCR7) play an important role in the invasion and metastasis of cancer. This study investigated the relationship between relative expression of CXCR4 and CCR7 mRNA, clinicopathological factors, and outcomes in patients with colorectal cancer (CRC). Patients and Methods: We studied 202 patients who underwent surgery for CRC. The expression levels of CXCR4 and CCR7 mRNA in cancerous tissue were measured using quantitative real-time reverse-transcriptase polymerase chain reaction. Results: High CCR7 mRNA expression levels in CRC tissues were positively associated with tumour size and were more frequently associated with cancer of the rectum than of the colon. Moreover, outcomes were significantly poorer in patients with high CCR7 mRNA expression than in those with low expression. On multivariate Cox regression analysis, a higher CCR7 mRNA expression level was a significant independent predictor of poorer overall survival in patients with CRC. Conclusion: Overexpression of CCR7 mRNA may be a useful independent prognostic factor in patients with CRC.