TY - JOUR T1 - Clinical Significance of Chemokine Receptor CXCR4 and CCR7 mRNA Expression in Patients With Colorectal Cancer JF - Anticancer Research JO - Anticancer Res SP - 4489 LP - 4495 DO - 10.21873/anticanres.15259 VL - 41 IS - 9 AU - SHINSUKE NAGASAWA AU - KAZUHITO TSUCHIDA AU - MANABU SHIOZAWA AU - YUKIHIKO HIROSHIMA AU - YAYOI KIMURA AU - ITARU HASHIMOTO AU - HAYATO WATANABE AU - KAZUKI KANO AU - MASAKATSU NUMATA AU - TORU AOYAMA AU - SUMITO SATO AU - TAKANOBU YAMADA AU - HIROSHI TAMAGAWA AU - NAOTO YAMAMOTO AU - TAKASHI OGATA AU - SOICHIRO MORINAGA AU - NORIO YUKAWA AU - YASUSHI RINO AU - MUNETAKA MASUDA AU - HIROSHI SAEKI AU - YOHEI MIYAGI AU - TAKASHI OSHIMA Y1 - 2021/09/01 UR - http://ar.iiarjournals.org/content/41/9/4489.abstract N2 - Background/Aim: The chemokine receptors C-X-C chemokine receptor type 4 (CXCR4) and C-C chemokine receptor type 7 (CCR7) play an important role in the invasion and metastasis of cancer. This study investigated the relationship between relative expression of CXCR4 and CCR7 mRNA, clinicopathological factors, and outcomes in patients with colorectal cancer (CRC). Patients and Methods: We studied 202 patients who underwent surgery for CRC. The expression levels of CXCR4 and CCR7 mRNA in cancerous tissue were measured using quantitative real-time reverse-transcriptase polymerase chain reaction. Results: High CCR7 mRNA expression levels in CRC tissues were positively associated with tumour size and were more frequently associated with cancer of the rectum than of the colon. Moreover, outcomes were significantly poorer in patients with high CCR7 mRNA expression than in those with low expression. On multivariate Cox regression analysis, a higher CCR7 mRNA expression level was a significant independent predictor of poorer overall survival in patients with CRC. Conclusion: Overexpression of CCR7 mRNA may be a useful independent prognostic factor in patients with CRC. ER -