TY - JOUR T1 - Therapeutic Effects of GGsTop<sup>®</sup> Gel in a Mouse Model of 5-Fluorouracil-induced Oral Mucositis With Reduced White Blood Cells JF - Anticancer Research JO - Anticancer Res SP - 4313 LP - 4319 DO - 10.21873/anticanres.15236 VL - 41 IS - 9 AU - ISSEI TAKEUCHI AU - KATSUYA TANAKA AU - KIMIKO MAKINO Y1 - 2021/09/01 UR - http://ar.iiarjournals.org/content/41/9/4313.abstract N2 - Background/Aim: In order to produce an animal model for oral mucositis induced by anticancer drugs, it is necessary to maintain an immunosuppressive state. We determined the optimal dose and frequency of 5-fluorouracil for a model mouse production. In addition, we used this model to investigate the effect of GGsTop® gelation on the therapeutic effect of oral mucositis. Materials and Methods: Changes in body weight and white blood cell count were measured to determine the optimal dosing schedule. The therapeutic effect of GGsTop® gel using chitosan was evaluated by observing changes in the ulcer area for three weeks and measuring collagen and glutathione concentrations in oral mucosal tissue. Results: The optimal dose and frequency of 5-fluorouracil were found to be 50 mg/kg every four days. It was revealed that the therapeutic effect of GGsTop® was enhanced by gelation. Conclusion: GGsTop® gel is suggested to be a promising formulation for the treatment of oral mucositis. ER -