RT Journal Article SR Electronic T1 Therapeutic Effects of GGsTop® Gel in a Mouse Model of 5-Fluorouracil-induced Oral Mucositis With Reduced White Blood Cells JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 4313 OP 4319 DO 10.21873/anticanres.15236 VO 41 IS 9 A1 ISSEI TAKEUCHI A1 KATSUYA TANAKA A1 KIMIKO MAKINO YR 2021 UL http://ar.iiarjournals.org/content/41/9/4313.abstract AB Background/Aim: In order to produce an animal model for oral mucositis induced by anticancer drugs, it is necessary to maintain an immunosuppressive state. We determined the optimal dose and frequency of 5-fluorouracil for a model mouse production. In addition, we used this model to investigate the effect of GGsTop® gelation on the therapeutic effect of oral mucositis. Materials and Methods: Changes in body weight and white blood cell count were measured to determine the optimal dosing schedule. The therapeutic effect of GGsTop® gel using chitosan was evaluated by observing changes in the ulcer area for three weeks and measuring collagen and glutathione concentrations in oral mucosal tissue. Results: The optimal dose and frequency of 5-fluorouracil were found to be 50 mg/kg every four days. It was revealed that the therapeutic effect of GGsTop® was enhanced by gelation. Conclusion: GGsTop® gel is suggested to be a promising formulation for the treatment of oral mucositis.