@article {TAKEUCHI4313, author = {ISSEI TAKEUCHI and KATSUYA TANAKA and KIMIKO MAKINO}, title = {Therapeutic Effects of GGsTop{\textregistered} Gel in a Mouse Model of 5-Fluorouracil-induced Oral Mucositis With Reduced White Blood Cells}, volume = {41}, number = {9}, pages = {4313--4319}, year = {2021}, doi = {10.21873/anticanres.15236}, publisher = {International Institute of Anticancer Research}, abstract = {Background/Aim: In order to produce an animal model for oral mucositis induced by anticancer drugs, it is necessary to maintain an immunosuppressive state. We determined the optimal dose and frequency of 5-fluorouracil for a model mouse production. In addition, we used this model to investigate the effect of GGsTop{\textregistered} gelation on the therapeutic effect of oral mucositis. Materials and Methods: Changes in body weight and white blood cell count were measured to determine the optimal dosing schedule. The therapeutic effect of GGsTop{\textregistered} gel using chitosan was evaluated by observing changes in the ulcer area for three weeks and measuring collagen and glutathione concentrations in oral mucosal tissue. Results: The optimal dose and frequency of 5-fluorouracil were found to be 50 mg/kg every four days. It was revealed that the therapeutic effect of GGsTop{\textregistered} was enhanced by gelation. Conclusion: GGsTop{\textregistered} gel is suggested to be a promising formulation for the treatment of oral mucositis.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/41/9/4313}, eprint = {https://ar.iiarjournals.org/content/41/9/4313.full.pdf}, journal = {Anticancer Research} }