@article {MIRKA4479, author = {HYNEK MIRKA and JIRI FERDA and GABRIELA KRAKOROVA and JOSEF VODICKA and PETR MUKENSNABL and ONDREJ TOPOLCAN and RADEK KUCERA}, title = {The Use of CT Pattern in Differentiating Non-invasive, Minimally Invasive and Invasive Variants of Lung Adenocarcinoma}, volume = {41}, number = {9}, pages = {4479--4482}, year = {2021}, doi = {10.21873/anticanres.15257}, publisher = {International Institute of Anticancer Research}, abstract = {Background/Aim: This study determined whether computed tomography (CT) is an appropriate means by which to differentiate non-invasive and minimally invasive forms of pulmonary adenocarcinoma from the invasive variant. Patients and Methods: A total of 64 patients (38 men and 26 women, aged 42-76, mean age 64), who underwent surgery for pulmonary adenocarcinoma and a chest CT no less than 1 month before surgery, were included in the study. Lesions exhibiting ground glass opacity or ground glass opacity with a solid component of 5 mm or smaller, were defined as minimally invasive or non-invasive adenocarcinomas. CT findings were correlated with histopathological examination. Results: Distinguishing minimally invasive and non-invasive adenocarcinoma from invasive adenocarcinoma using CT was achieved with a sensitivity of 77.7\%, a specificity of 97.8\%, a positive predictive value of 93.3\%, and a negative predictive value of 91.8\%. Conclusion: CT can be useful in assessing the degree of invasiveness of pulmonary adenocarcinoma and is a potential tool for the individualization of treatment.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/41/9/4479}, eprint = {https://ar.iiarjournals.org/content/41/9/4479.full.pdf}, journal = {Anticancer Research} }