RT Journal Article
SR Electronic
T1 Soluble Factors Involved in Cancer Cell–Macrophage Interaction Promote Breast Cancer Growth
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 4249
OP 4258
DO 10.21873/anticanres.15229
VO 41
IS 9
A1 KIMIHIRO YONEMITSU
A1 YUKO MIYASATO
A1 TAKUYA SHIOTA
A1 YUSUKE SHINCHI
A1 YUKIO FUJIWARA
A1 SEIJI HOSAKA
A1 YUTAKA YAMAMOTO
A1 YOSHIHIRO KOMOHARA
YR 2021
UL http://ar.iiarjournals.org/content/41/9/4249.abstract
AB Background/Aim: Recent studies have indicated the clinical significance of tumor-associated macrophages (TAMs) in breast cancer; however, the detailed mechanisms of cell–cell interactions between TAMs and cancer cells remain unclear. Materials and Methods: In vitro cell culture studies using human monocyte-derived macrophages and breast cancer cell lines were performed to test which cytokines would be involved in cell-cell interactions between cancer cells and macrophages. In addition, studies using human resected samples and animal breast cancer models were performed to examine the significance of TAMs in cancer development. Results: Osteopontin, HB-EGF, and IL-6 were suggested to be macrophage-derived growth factors for breast cancer cells. FROUNT inhibitor significantly blocked TAM infiltration and subcutaneous tumor growth in an E0771 mouse breast cancer model. Conclusion: TAMs express growth factors, such as osteopontin, for cancer cells, and targeting of TAM infiltration might be a promising approach for anti-breast cancer therapy.