RT Journal Article SR Electronic T1 Fibrin/fibrinogen Degradation Products Are Associated With Tumor Stage and Prognosis in Patients Undergoing Resection of Esophageal Cancer JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 4523 OP 4527 DO 10.21873/anticanres.15263 VO 41 IS 9 A1 MAKOTO SAKAI A1 MAKOTO SOHDA A1 SHINTARO UCHIDA A1 ARISA YAMAGUCHI A1 TAKAYOSHI WATANABE A1 HIDEYUKI SAITO A1 YASUNARI UBUKATA A1 NOBUHIRO NAKAZAWA A1 KENGO KURIYAMA A1 AKIHIKO SANO A1 HIROOMI OGAWA A1 TAKEHIKO YOKOBORI A1 KEN SHIRABE A1 HIROSHI SAEKI YR 2021 UL http://ar.iiarjournals.org/content/41/9/4523.abstract AB Background/Aim: To investigate the significance of preoperative fibrin/fibrinogen degradation products (FDP) in patients with esophageal cancer (EC), we examined the association between the preoperative FDP level and clinicopathological features in patients with EC who underwent McKeown esophagectomy with gastric tube reconstruction without neoadjuvant therapy. Patients and Methods: Ninety patients with EC who underwent surgery between 2006 and 2014 were included in this study. We investigated the association of FDP levels with clinicopathological features and prognosis. Results: Multivariate analysis revealed increased FDP level and pathological tumor depth to be independent prognostic factors for overall survival (OS) (p=0.008 and p=0.002, respectively). In addition, FDP levels were significantly positively associated with more advanced pathological TNM stage as a continuous variable (p for trend=0.002). Conclusion: The preoperative FDP level was associated with a poor prognosis and was an independent prognostic factor for the OS of EC patients who underwent esophagectomy. Furthermore, the tumor stage-related increase in FDP indicated that a high FDP level is associated with tumor progression in patients with EC.