RT Journal Article
SR Electronic
T1 Crypts in Asymmetric Fission in Endoscopic Biopsies from German Patients With Inflammatory Bowel Disease
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 4401
OP 4405
DO 10.21873/anticanres.15245
VO 41
IS 9
A1 CARLOS A. RUBIO
A1 CORINNA LANG-SCHWARZ
A1 MICHAEL VIETH
YR 2021
UL http://ar.iiarjournals.org/content/41/9/4401.abstract
AB Background/Aim: We previously found in Swedish patients with inflammatory bowel disease (IBD), crypts in symmetric fission (CSF) and in asymmetric fission (CAF). This study aimed to examine CSF and CAF in a cohort of German patients with IBD. Patients and Methods: H&E-sections from 106 IBD-patients [59 ulcerative colitis (UC) and 47 Crohn colitis (CCs)] were analysed. Results: A total of 588 crypts in fission (CF) were found; 342 (58.2%) in UC and 246 (41.8%) in CCs. Out of the 505 CAFs found, 304 (60.2%) were recorded in UC, and 201(39.8%) in CCs (p=0.15272). Conclusion: Despite that German and Swedish populations reside in disparate geographical regions with different ecological milieus, the proportions of CAF and CSF were similar, thereby suggesting that CAF and CSF develop in IBD independently of the local environmental conditions in the two regions.