PT - JOURNAL ARTICLE AU - RUBIO, CARLOS A. AU - LANG-SCHWARZ, CORINNA AU - VIETH, MICHAEL TI - Crypts in Asymmetric Fission in Endoscopic Biopsies from German Patients With Inflammatory Bowel Disease AID - 10.21873/anticanres.15245 DP - 2021 Sep 01 TA - Anticancer Research PG - 4401--4405 VI - 41 IP - 9 4099 - http://ar.iiarjournals.org/content/41/9/4401.short 4100 - http://ar.iiarjournals.org/content/41/9/4401.full SO - Anticancer Res2021 Sep 01; 41 AB - Background/Aim: We previously found in Swedish patients with inflammatory bowel disease (IBD), crypts in symmetric fission (CSF) and in asymmetric fission (CAF). This study aimed to examine CSF and CAF in a cohort of German patients with IBD. Patients and Methods: H&E-sections from 106 IBD-patients [59 ulcerative colitis (UC) and 47 Crohn colitis (CCs)] were analysed. Results: A total of 588 crypts in fission (CF) were found; 342 (58.2%) in UC and 246 (41.8%) in CCs. Out of the 505 CAFs found, 304 (60.2%) were recorded in UC, and 201(39.8%) in CCs (p=0.15272). Conclusion: Despite that German and Swedish populations reside in disparate geographical regions with different ecological milieus, the proportions of CAF and CSF were similar, thereby suggesting that CAF and CSF develop in IBD independently of the local environmental conditions in the two regions.