PT  - JOURNAL ARTICLE
AU  - RUBIO, CARLOS A.
AU  - LANG-SCHWARZ, CORINNA
AU  - VIETH, MICHAEL
TI  - Crypts in Asymmetric Fission in Endoscopic Biopsies from German Patients With Inflammatory Bowel Disease
AID  - 10.21873/anticanres.15245
DP  - 2021 Sep 01
TA  - Anticancer Research
PG  - 4401--4405
VI  - 41
IP  - 9
4099  - http://ar.iiarjournals.org/content/41/9/4401.short
4100  - http://ar.iiarjournals.org/content/41/9/4401.full
SO  - Anticancer Res2021 Sep 01; 41
AB  - Background/Aim: We previously found in Swedish patients with inflammatory bowel disease (IBD), crypts in symmetric fission (CSF) and in asymmetric fission (CAF). This study aimed to examine CSF and CAF in a cohort of German patients with IBD. Patients and Methods: H&E-sections from 106 IBD-patients [59 ulcerative colitis (UC) and 47 Crohn colitis (CCs)] were analysed. Results: A total of 588 crypts in fission (CF) were found; 342 (58.2%) in UC and 246 (41.8%) in CCs. Out of the 505 CAFs found, 304 (60.2%) were recorded in UC, and 201(39.8%) in CCs (p=0.15272). Conclusion: Despite that German and Swedish populations reside in disparate geographical regions with different ecological milieus, the proportions of CAF and CSF were similar, thereby suggesting that CAF and CSF develop in IBD independently of the local environmental conditions in the two regions.