PT  - JOURNAL ARTICLE
AU  - A. KALOGERAKI
AU  - M. KAFOUSI
AU  - P. IEROMONACHOU
AU  - E. GIANNIKAKI
AU  - T. VREKOUSSIS
AU  - O. ZORAS
AU  - D. TSIFTSIS
AU  - E. STATHOPOULOS
TI  - Telomerase Activity as a Marker of Invasive Ductal Breast Carcinomas on FNABs and Relationship to Other Prognostic Variables
DP  - 2005 May 01
TA  - Anticancer Research
PG  - 1927--1930
VI  - 25
IP  - 3B
4099  - http://ar.iiarjournals.org/content/25/3B/1927.short
4100  - http://ar.iiarjournals.org/content/25/3B/1927.full
SO  - Anticancer Res2005 May 01; 25
AB  - To study the activity of telomerase and the relationship between telomerase and other prognostic variables in cases of invasive ductal breast carcinomas, fifty fine-needle aspiration biopsies (FNABs) obtained from the same number of female patients, diagnosed cytologically and confirmed histologically after surgery, were examined. The same cases were studied immunocytochemically using monoclonal antibodies to telomerase, estradiol receptors (ER) and HER-2 (CB11) and a standard alkaline phosphatase (APAAP) method. Telomerase activity was found in 72% of the carcinomas studied. An association was found between telomerase activity, ER receptors and HER-2 expression (p<0.005). A relationship between telomerase activity, histological grade and lymph node status (LNS) was found as well (p<0.005). The above results seem to be significant prognostic factors and should be taken into consideration in the follow-up of patients after appropriate treatment for breast cancer Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved