RT Journal Article
SR Electronic
T1 The Cytotoxic Effect of Two Chemotypes of Essential Oils from the Fruits of <em>Angelica archangelica</em> L.
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1877
OP 1880
VO 25
IS 3B
A1 STEINTHOR SIGURDSSON
A1 HELGA M. ÖGMUNDSDOTTIR
A1 SIGMUNDUR GUDBJARNASON
YR 2005
UL http://ar.iiarjournals.org/content/25/3B/1877.abstract
AB Background: The aim of this work was to study the constituents and cytotoxicity of the essential oils from the fruits of Angelica archangelica growing in Iceland. Materials and Methods: Three samples of essential oils were prepared by steam distillation. Their composition was established with GC/MS. The effects of the oils were examined in PANC-1 human pancreas cancer cells and Crl mouse breast cancer cells in concentrations ranging from 10-400 μg/ml, measuring the reduction of the tetrazolium salt 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulphophenyl)-2H-tetrazolium (MTS) by mitochondrial enzymes. Results: Two types of essential oils were found, differing mainly in the absence or presence of β-phellandrene. The ED50 of the oils ranged from 48.6 μg/ml to 108.3 μg/ml for PANC-1 and 48.0 μg/ml to 91.8 μg/ml for Crl cells. Conclusion: The cytotoxic activity of the essential oils was independent of the quantity of their main components. Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved