RT Journal Article
SR Electronic
T1 Monosomy 13 in Mammary Myofibroblastoma
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3747
OP 3751
DO 10.21873/anticanres.15166
VO 41
IS 8
A1 PANAGOPOULOS, IOANNIS
A1 GORUNOVA, LUDMILA
A1 LUND-IVERSEN, MARIUS
A1 HEIM, SVERRE
YR 2021
UL http://ar.iiarjournals.org/content/41/8/3747.abstract
AB Background/Aim: Myofibroblastoma of the breast is a rare benign mesenchymal tumor whose morphology is similar to that of spindle-cell lipoma. The few hitherto genetically investigated mammary myofibroblastomas have been shown to have had loss of material from chromosome 13, changes that are also common in spindle-cell lipoma. Our aim was to add to the existing knowledge of genetic aberrations in mammary myofibroblastoma by investigating another such tumor. Materials and Methods: Cytogenetic and array comparative genome hybridization (aCGH) analyses were performed on a surgically removed mammary myofibroblastoma from a 76-year-old man. Results: Short-term cultured cells from the tumor showed the karyotype 45,XY,-13[3]/44~45,idem,add(19)(q13)[cp2]. aCGH detected loss of one entire chromosome 13 and heterozygous loss from 19q between sub-band 19q13.12 and 19qter. Conclusion: These findings add to the evidence that loss of 13q material is typical of mammary myofibroblastomas.